444) Nicotine, an ____I____, stimulates ____II____ gland to release adrenaline and nor-adrenaline into blood circulation, both of which ___III___ blood pressure and increase heart rate. Smoking is associated with increased incidence of cancers of lung, urinary bladder and throat, bronchitis, emphysema, coronary heart disease, gastric ulcer, etc. Tobacco chewing is associated with increased risk of cancer of the oral cavity. Smoking increases ____IV____ content in blood and reduces the concentration of haembound ____V____.